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Osteoporosis
 
 

Osteoporosis is a common bone disease that affects both men and women, usually as they grow older. Fortunately, you can take steps to reduce your risk of developing osteoporosis and avoiding the often-debilitating bone fractures that can result from this disease. If you already have osteoporosis, new medications are available to slow or even stop its progression.

Fast Facts

  • Age is not the only risk factor for osteoporosis. Other diseases and even medications can cause this condition.
  • A simple diagnostic test known as a bone density test can provide valuable information about your bone strength.
  • New medications exist to slow and even stop the progression of osteoporosis.

What is osteoporosis?
Osteoporosis is a silent disease of the bones that makes them weaken and prone to fracture. Bone is living tissue that is in a constant state of regeneration. As old bone is removed (bone resorption) it is replaced by new bone (bone formation). By their mid-30s, most people begin to gradually lose bone strength as the balance between bone resorption and bone formation shifts, so that more bone is lost than can be replaced. As a result, bones become thinner and structurally weaker.

The disease is “silent” because there are no symptoms when you have osteoporosis, and the condition may come to attention only after you break a bone. When you have osteoporosis, this can occur even after a minor injury, such as a fall. The most common fractures occur at the spine, wrist and hip. Spine and hip fractures in particular may lead to chronic pain, long-term disability and even death. The goal of treating osteoporosis is to prevent such fractures in the first place.

What causes osteoporosis?
Many factors will increase your risk of developing osteoporosis and suffering a fracture. Some of these risk factors can be changed, while others cannot. Recognizing your own risk factors is important so that you can take steps to prevent this condition from developing or treat it before it becomes worse. Major risk factors include:

  • Older age (starting in the mid-30s but accelerating after 50)
  • Non-Hispanic white and Asian ethnic background
  • Small bone structure
  • Family history of osteoporosis or osteoporosis-related fracture in a parent or sibling
  • Previous fracture following a low-level trauma, especially after age 50
  • Sex hormone deficiency, particularly estrogen deficiency, both in women (e.g. menopause) and men
  • Anorexia nervosa
  • Cigarette smoking
  • Alcohol abuse
  • Low dietary intake or absorption of calcium and vitamin D
  • Sedentary lifestyle or immobility
  • Medications: glucocorticoid medications such as prednisone; excess thyroid hormone replacement; the blood thinner heparin; certain anti-convulsant medications such as phenytoin and ethotoin.
  • Certain diseases can affect bone, such as endocrine disorders (hyperthyroidism, hyperparathyroidism, Cushing's disease, etc.) and inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, etc.)

Who gets osteoporosis?
Osteoporosis is more common in older individuals and non-Hispanic white women, but can occur at any age, in men as well as in women, and in all ethnic groups.

In the U.S., about 8 million women and 2 million men have osteoporosis. Those over the age of 50 are at greatest risk of developing osteoporosis and suffering related fractures. In this age group, one in two women and one in six men, will suffer an osteoporosis-related fracture at some point in their life. Non-Hispanic white and Asian people are most likely to experience osteoporosis and osteoporosis-related fractures. Hispanic and non-Hispanic black people can also develop osteoporosis and related fractures, but have a lower risk when compared to non-Hispanic whites and Asians.

Diagnosis and treatment
A simple test that measures the bone mineral density (BMD) at different parts of your body, such as your spine and your hip, can help determine if you have osteoporosis. Dual energy x-ray absorptiometry (DEXA) is the best current test to measure BMD. The test is quick and painless; it is similar to having an x-ray taken, but uses much less radiation. Even so, pregnant women should not have this test done in order to avoid any risk of damaging the developing fetus.

The results of the DEXA test are scored in comparison to the BMD of young, healthy individuals, resulting in a measurement called a T-score. If your T-score is –2.5 or lower, you are considered to have osteoporosis and therefore at high risk for a fracture. T-scores between –1.0 and –2.5 are generally considered to show “osteopenia.” The risk of fractures is generally lower in people with osteopenia when compared with those with osteoporosis, but if bone loss continues, the risk for fracture increases.

To maintain bone health:

  • Make sure there is enough calcium in your diet (1000 mg per day of calcium for women before menopause and 1500 mg per day for women who are postmenopausal and are not taking estrogen replacement therapy). Calcium dosages should be split up so that you get 1/3 of the total dose three times per day.
  • Get adequate vitamin D intake, which is important for calcium absorption and to maintain muscle strength (400IU per day until age 60, 600-800 IU per day after age 60).
  • Get regular exercise, especially weight bearing exercise such as walking and weight training.

A number of medications are also used for the prevention and treatment of osteoporosis:

  • Bisphosphonates: Alendronate (Fosamax) and risedronate (Actonel) are pills that need to be taken on an empty stomach with water. These medications help slow down bone loss and have been shown to decrease the risk of fractures.
  • Calcitonin (Calcimar, Miacalcin): This medication is a hormone made from the thyroid gland and is usually given as a nasal spray or as an injection under the skin. It may help prevent spine fractures, and is also helpful to control pain after an osteoporotic vertebral (spine) fracture.
  • Estrogen or Hormone Replacement Therapy: Estrogen therapy alone or in combination with another hormone, progestin, has been shown to decrease the risk of osteoporosis and osteoporotic fractures in women. However, the combination of estrogen with a progestin has been shown to increase the risk for breast cancer, strokes, heart attacks and blood clots. Estrogens alone may increase the risk of strokes. Given the complexity of this decision, consult with your doctor about whether hormone replacement therapy is appropriate for you.
  • Selective Estrogen Receptor Modulators (SERMs): These medications mimic estrogens good effects on bones without some of the serious side effects such as breast cancer. Raloxifene ( Evista ) decreases spine fractures in women, and is approved for use only in women at this time.
  • Teriparatide (Forteo): Teriparatide is a form of parathyroid hormone that helps stimulate bone formation. It is approved for use in postmenopausal women and men at high risk for osteoporotic fracture. It is given as a daily injection under the skin and can be used for up to 2 years. If you have ever had radiation treatment to your bones or if you have parathyroid hormone levels that are already too high, you should not take this medication.

Prevention
Lifestyle changes may be the best way of preventing osteoporosis:

  • Make sure you are getting enough calcium in your diet (roughly 1000-1500 mg/day, but will depend on your age)
  • Make sure you are getting enough vitamin D (between 400-800 IU/day)
  • Stop smoking
  • Avoid excess alcohol intake
  • Engage in weight-bearing exercises
  • Treat underlying medical conditions that can cause osteoporosis
  • Minimize or change medications that can cause osteoporosis; never stop taking any medication without speaking with your doctor first
  • If you are at high risk for falls, consider using hip protectors (e.g. SAFEHIP ®), which will help prevent a hip fracture if you fall

Broader health impact of osteoporosis
The most health-threatening consequence of osteoporosis is a fracture. Spine and hip fractures especially may lead to chronic pain, long-term disability and even death. The major goal of treating osteoporosis is to prevent fractures.

Living with osteoporosis
If you have osteoporosis, it is important not only to help prevent further bone loss, but also to prevent a fracture. Eliminate hazards in the house that can increase your risk of falling (remove loose wires or throw rugs, install grab bars in the bathroom and non-skid mats near sinks and in the tub, etc.) Be careful when you are carrying or lifting items, as this could cause a spine fracture. Wear sturdy shoes, especially in winter. Use a cane or walker if you have balance problems or have other difficulties walking.

Points to remember

  • Make sure there is enough calcium and vitamin D in your diet.
  • Get regular exercise.
  • Eliminate lifestyle choices that increase your risk of osteoporosis.

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